EQUIPMENT
DRUG
- Ichikawa Laboratory
- Izumo Plant (Plant No. 1)
- Izumo Plant (Plant No. 1) Purification Equipment
- Izumo Plant (Plant No. 1) Crushing/Grinding Equipment
- Izumo Plant (Plant No. 1) Peptide/Nucleic Acid Drug Manufacturing Equipment
- KNC Bioresearch Center
Ichikawa Laboratory
| Equipment | Material | Capacity / Specifications | No. of units | Notes: Operating range, etc. |
|---|---|---|---|---|
| Reactor vessel | SUS | 500 L | 1 | Temperature: -15℃ to 120℃ |
| SUS | 1,000 L | 1 | Temperature: -70℃ to 120℃ (single-medium heating/cooling) |
|
| GL | 300 L - 2,000 L |
5 | Temperature: -15℃ to 120℃ | |
| Teflon | 240 L | 1 | Temperature: -100℃ to 120℃ All fluoropolymer-lined unit (SUS body) |
|
| Column chromatography system | SUS | 60 L - 120 L |
3 | Pressure: 0.2 MPa to 0.3 MPa |
| Centrifuge | SUS | 24 inch | 2 | Mobile ・Fluoropolymer-lined liquid contact part ・Top-vented, with operating casing |
| Conical dryer | GL | 300 L | 1 | Temperature: 20℃ to 120℃ |
| Clean room | - | Class 100,000 | 1 | 100 L dryer installed |
Izumo Plant (Plant No. 1)
| Equipment | Material | Capacity / Specifications | No. of units | Notes: Operating range, etc. |
|---|---|---|---|---|
| Reactor vessel | SUS | 500 L | 1 | Temperature: -70℃ to 130℃ |
| SUS | 1,000 L | 1 | Temperature: -15℃ to 250℃ | |
| SUS | 2,000 L | 1 | Temperature: -15℃ to 130℃ | |
| GL | 200 L - 6,000 L |
12 | Temperature: -15℃ to 130℃ | |
| GL | 700 L 1,200 L |
2 | Temperature: -70℃ to 130℃ | |
| Autoclave | SUS | 1,000 L | 1 | Pressure: up to 0.9 MPa |
| GL | 2,000 L | 1 | Pressure: up to 0.5 MPa | |
| Column chromatography system | SUS | 140 L - 300 L |
3 | Pressure: 0.2 MPa to 0.5 MPa |
| Centrifuge | SUS | 30 inch | 1 | Mobile |
| Hastelloy | 30 inch | 1 | Mobile | |
| Hastelloy | 42 inch | 2 | Bottom-vented, continuous | |
| Conical dryer | SUS | 500 L | 2 | Temperature: 20℃ to 110℃ |
| GL | 500 L - 1,000 L |
4 | Temperature: 20℃ to 110℃ | |
| Clean room | - | Class 100,000 | 3 | GL 200 L - 4,000 L reactor vessel installed |
Izumo Plant (Plant No. 1) Purification Equipment
| Equipment | Material | Capacity / Specifications | No. of units | Notes: Operating range, etc. |
|---|---|---|---|---|
| Clean room | - | Class 100,000 | 3 | |
| Melter | GL | 200 L 1,000 L |
2 | Temperature: -15℃ to 130℃ |
| GL | 4,000 L | 1 | Temperature: 30℃ to 100℃ | |
| Crystallizer | GL | 200 L - 4,000 L |
3 | Temperature: -15℃ to 110℃ |
| Centrifuge | Hastelloy | 42 inch | 1 | Bottom-vented, continuous |
| Conical dryer | GL | 500 L 1,500 L |
2 | Temperature: 20℃ to 110℃ |
Izumo Plant (Plant No. 1) Crushing/Grinding Equipment
| Equipment | Material | Capacity / Specifications | No. of units | Notes: Operating range, etc. |
|---|---|---|---|---|
| Clean room | - | Class 100,000 | 1 | Low humidity-compliant |
| - | Class 100,000 | 2 | ||
| Grinder | ||||
| Quick mill | SUS | 1 | Crusher Cutter + screen -type |
|
| Jet-O-Mill | SUS | 0.5 kg/hr - 2 kg/hr |
1 | Airflow grinder |
| Counter jet mill | SUS | 5 kg/hr - 30 kg/hr |
1 | Airflow grinder Allows grinding under nitrogen flow |
| Spiral jet mill | SUS | 3 kg/hr - 20 kg/hr |
1 | |
| Lab mill | SUS | 10 g or more | 1 | Mechanical grinding, for testing |
| Hammer mill | SUS | 5 kg/hr - 30 kg/hr 20 kg/hr - 80 kg/hr |
2 | Mechanical grinding Hammer rotation speed: Max 130 m/s |
| Pin mill | SUS | 15 kg/hr - 20 kg/hr |
1 | Mechanical grinding Allows grinding under nitrogen flow |
Izumo Plant (Plant No. 1) Peptide/Nucleic Acid Drug Manufacturing Equipment
| Equipment | Material | Capacity / Specifications | No. of units | Notes: Operating range, etc. |
|---|---|---|---|---|
| Solid-phase synthesizer |
GL | 1 L - 10 L |
1 | Oligonucleic acid/peptide -capable |
| GL | 250 L - 750 L |
1 | ||
| Peptide solid- phase synthesizer |
- | Several mg - several g |
1 | |
| - | Several mg - several 10 g |
1 | ||
| Nucleic acid solid- phase synthesizer |
- | Several mg - several 10 g |
3 | |
| High-performance chromatography system |
- | 40 L /h - 100 L/h |
1 | High-capacity, reverse-phase, preparative purification Temperature: 40℃ |
| Low-pressure chromatography system |
- | up to 120 L/h | 1 | High-capacity ion exchange purification Temperature: 4℃ to 50℃ |
| High-pressure column |
SUS | Inner diameter 150 mm |
1 | For high-capacity, reverse- phase preparation |
| SUS | Inner diameter 250 mm |
1 | ||
| Low-pressure column |
Acrylic | Inner diameter 200 mm |
1 | For high-capacity ion exchange purification |
| GL | Inner diameter 300 mm |
1 | ||
| Reactor vessel | GL | 5 L | 1 | De-protection reaction |
| Pressure-resistant reactor |
SUS | 10 L | 1 | De-protection reaction |
| Rotary evaporator | GL | 10 L 20 L |
2 | |
| Ultrafiltrator | - | up to 100 L/h (concentration) |
1 | Flat sheet-type Ultrafiltration membrane (UF membrane) |
| Freeze-dryer | - | Cold trap 50 L | 1 | Shelf type |
| Clean room | - | Class 100,000 | 1 | |
| Safety cabinet | - | Class 10,000 | 1 | |
| Water purification equipment |
- | 250 L/h (production capacity) |
1 | RO+EDI+UF membrane (low-endotoxin water) |
KNC Bioresearch Center
| Equipment | Material | Capacity / Specifications | No. of units | Notes: Operating range, etc. |
|---|---|---|---|---|
| Culturing equipment | SUS | 5 L - 5,000 L |
9 | Recombinant microorganism (GILSP) -compliant |
| Solid-liquid separation apparatus | - | 5 | Various | |
| Microbial homogenizer | - | 22 L/hr 1,400 L/hr |
2 | High-pressure homogenizer (1,000 bar) |
| Membrane filtration apparatus | - | 9 | Various | |
| Purification apparatus | - | Multiple | Various | |
| Clean room | - | Class 100,000 | 2 | Column purification room, etc., for protein and other materials |
| Preparative chromatography apparatus | SUS Glass PP PVC |
Multiple | Various | |
| Protein fraction collector |
- | 3 | ||
| CPC (Centrifugal partition chromatograph) |
- | 3 | Countercurrent distribution Chromatography |
|
| Jar fermentor | - | 2 L - 10 L |
11 | |
| Freeze-dryer | - | 6 | Laboratory use, benchtop model | |
| Bioexperimentation air handling system |
- | 3 | For P-1 level biohazard containment |
|
| Clean room | - | Class 10,000 | 2 | For sterile processing |