Metabolite Synthesis

Technology

We prepare metabolites of drug and food ingredient using mammalian tissue homogenates or genetically modified microorganisms. We also provide standard samples to meet your needs in any phases of drug development.
Employment of phase II metabolism enzyme, UDP-glucuronosyltransferase for instance, in genetically modified microorganism or mammalian tissue homogenate can give milligrams to grams of metabolites. Glucuronate conjugate, which is hard to synthesize chemically, has been prepared successfully. If chemical synthesis is easier, we will do so.

Safety study of drug metabolites has been required and standard samples of metabolites are necessary for the study. We are ready to prepare metabolites formed by cytochrome P-450 and glucuronate conjugates including acylglucuronides using enzyme. We provide standard samples of metabolites to meet your needs in drug development phases such as structure determination, measurement of blood concentration, safety testing, and medicinal effect testing.

Experiences

• Biosynthesis of glucuronide conjugate using mammalian microsome and human UDP-glucuronyl transferase.
• Biosynthesis of CYP metabolites and glucuronide cojugates using mammlian tissue homogenate, without disclosure of drug chemical strucure from customers.

A convenient tool for metabolites synthesis is in our hand.