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Combinatorial Chemistry
Technology
Custom library of a variety of molecules in small quantity
is prepared by high
throughput liquid phase combinatorial parallel synthesis and purification.
We also provide scaffold for combinatorial synthesis, various building blocks, and candidate molecule found by (in-silico) screenings.
Our service extends to consultation by medicinal chemist on scaffold and building block for custom library as well as library design and synthetic route optimization.
Taking the idea of combinatorial chemistry, we have proposed to facilitate R&D studies, too.
Experiences
- Amidation (acid chloride, active ester)
- Sulfamidation (sulfonyl chloride)
- Deprotection (Boc, Cbz, Bz, Fmoc, ester)
- Urea formation (isocyante, isothiocyanate)
- Ether formation (alkylhalide+base)
- Amination (alkylhalide+base, reductive amination, palladium coupling)
- Suzuki coupling (Pd(OAc)2{PPh3)
- Triazole synthesis (substituted hydrazine)
Equipment
| Synthesizer | ||
|---|---|---|
| Name | Quantity | Maker |
| CCL-2400 | 5 | TOKYO RIKAKIKAI |
| CCL-4S | 1 | TOKYO RIKAKIKAI |
| Metz 6 Position Parallel Reaction Station | 1 | Radleys |
| Purification | ||
| Gilson215, UV (Preparative LC/MS) | 1 | Gilson |
| ZQ2000, UV (Preparateive/Analysis LC/MS) | 1 | Waters-Micromass |
| HS1-0B21-GKCUV(Preparative FC) | 1 | Biotage |
| Others | ||
| Platform LCZ, UV (LC/MS) | 1 | Waters-Micromass |
| ZQ2000, UV (LC/MS) | 1 | Waters-Micromass |
| HT-4 SeriesII (Centrifuge) | 1 | |
| AES2050DDA (Centrifuge) | 1 | |
| SpeedVac SC210A (Centrifuge) | 1 | |
Capability
Liquid phase parallel synthesis and purification (miligrams to tens miligrams)
DMSO solution is producible
